5DNR

Aurora A Kinase in complex with ATP in space group P41212

Summary for 5DNR

Entry DOI	10.2210/pdb5dnr/pdb
Descriptor	Aurora kinase A, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	aurora a kinase, mitotic kinase, ppi, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	32187.99
Authors	Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,McKenzie, G.,Huggins, D.,Stockwell, S.,Stokes, J.A.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,Venkitaraman, A. (deposition date: 2015-09-10, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,Huggins, D.J.,Stockwell, S.R.,Stokes, J.E.,Tan, Y.S.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6:28528-28528, 2016 Cited by PubMed: 27339427 DOI: 10.1038/srep28528 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation