5DLT

Crystal structure of Autotaxin (ENPP2) with 7-alpha-hydroxycholesterol

Summary for 5DLT

Entry DOI	10.2210/pdb5dlt/pdb
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (10 entities in total)
Functional Keywords	autotaxin, enpp2, lpa, steroids, bile salts, hydrolase
Biological source	Rattus norvegicus (norway Rat)
Total number of polymer chains	1
Total formula weight	98876.31
Authors	Hausmann, J.,Joosten, R.P.,Perrakis, A. (deposition date: 2015-09-07, release date: 2016-04-13, Last modification date: 2024-01-10)
Primary citation	Keune, W.J.,Hausmann, J.,Bolier, R.,Tolenaars, D.,Kremer, A.,Heidebrecht, T.,Joosten, R.P.,Sunkara, M.,Morris, A.J.,Matas-Rico, E.,Moolenaar, W.H.,Oude Elferink, R.P.,Perrakis, A. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7:11248-11248, 2016 Cited by PubMed: 27075612 DOI: 10.1038/ncomms11248 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation