5DLM

Complex of Influenza M2e and Antibody

Summary for 5DLM

• Entry DOI: 10.2210/pdb5dlm/pdb
• Descriptor: Heavy chain of monoclonal antibody, Light chain of monoclonal antibody, Matrix protein 2, ... (5 entities in total)
• Functional Keywords: complex, antibody, extracellular domain, immune system
• Biological source: Mus musculus (House Mouse); More
• Cellular location: Virion membrane : A4U6V3
• Total number of polymer chains: 6
• Total formula weight: 99240.48

Authors

Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X. (deposition date: 2015-09-07, release date: 2015-10-28, Last modification date: 2024-11-13)

Primary citation

Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X.
Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.
J.Virol., 90:611-615, 2015

PubMed Abstract: We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.

PubMed: 26468526
DOI: 10.1128/JVI.02105-15

Experimental method

X-RAY DIFFRACTION (2.2 Å)