5DLM

Complex of Influenza M2e and Antibody

Summary for 5DLM

Entry DOI	10.2210/pdb5dlm/pdb
Descriptor	Heavy chain of monoclonal antibody, Light chain of monoclonal antibody, Matrix protein 2, ... (5 entities in total)
Functional Keywords	complex, antibody, extracellular domain, immune system
Biological source	Mus musculus (House Mouse) More
Cellular location	Virion membrane : A4U6V3
Total number of polymer chains	6
Total formula weight	99240.48
Authors	Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X. (deposition date: 2015-09-07, release date: 2015-10-28, Last modification date: 2024-11-13)
Primary citation	Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X. Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody. J.Virol., 90:611-615, 2015 Cited by PubMed Abstract: We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies. PubMed: 26468526 DOI: 10.1128/JVI.02105-15 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation