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5DLM

Complex of Influenza M2e and Antibody

Summary for 5DLM
Entry DOI10.2210/pdb5dlm/pdb
DescriptorHeavy chain of monoclonal antibody, Light chain of monoclonal antibody, Matrix protein 2, ... (5 entities in total)
Functional Keywordscomplex, antibody, extracellular domain, immune system
Biological sourceMus musculus (House Mouse)
More
Cellular locationVirion membrane : A4U6V3
Total number of polymer chains6
Total formula weight99240.48
Authors
Cho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X. (deposition date: 2015-09-07, release date: 2015-10-28, Last modification date: 2024-11-13)
Primary citationCho, K.J.,Schepens, B.,Moonens, K.,Deng, L.,Fiers, W.,Remaut, H.,Saelens, X.
Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.
J.Virol., 90:611-615, 2015
Cited by
PubMed Abstract: We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
PubMed: 26468526
DOI: 10.1128/JVI.02105-15
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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건을2025-07-23부터공개중

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