5DJM
Structure of WT Human Glutathione Transferase in complex with cisplatin in the absence of glutathione.
Summary for 5DJM
Entry DOI | 10.2210/pdb5djm/pdb |
Related | 5DCG 5DJL |
Descriptor | Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PLATINUM (II) ION, ... (4 entities in total) |
Functional Keywords | anticancer cisplatin, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47731.25 |
Authors | Parker, L.J. (deposition date: 2015-09-02, release date: 2016-11-02, Last modification date: 2023-09-27) |
Primary citation | Parker, L.J.,Italiano, L.C.,Hancock, N.C.,Aitken, J.,Harris, H.H.,Hansen, G.,Ascher, D.B.,Morton, C.J.,Parker, M.W.,Lo Bello, M. A structure-based mechanism of cisplatin resistance mediated by Glutathione Transferase P1-1 Proc.Natl.Acad.Sci.USA, 2019 |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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