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5DIG

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a trifluoromethyl-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-5-[4-hydroxy-2-(trifluoromethyl)phenyl]-7a-methyloctahydro-1H-inden-1-ol

Summary for 5DIG
Entry DOI10.2210/pdb5dig/pdb
Related5DI7 5DID 5DIE 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, (1S,3aR,5S,7aS)-5-[4-hydroxy-2-(trifluoromethyl)phenyl]-7a-methyloctahydro-1H-inden-1-ol, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationIsoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight62561.64
Authors
Primary citationNwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W.
Predictive features of ligand-specific signaling through the estrogen receptor.
Mol.Syst.Biol., 12:864-864, 2016
Cited by
PubMed: 27107013
DOI: 10.15252/msb.20156701
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.24 Å)
Structure validation

217705

건을2024-03-27부터공개중

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