5DIE

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a trifluoro-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-7a-methyl-5-(2,3,5-trifluoro-4-hydroxyphenyl)octahydro-1H-inden-1-ol

5DIE の概要

• エントリーDOI: 10.2210/pdb5die/pdb
• 関連するPDBエントリー: 5DI7 5DID 5DIG 5DK9 5DKB 5DKE 5DKG 5DKS 5DL4
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, (1S,3aR,5S,7aS)-7a-methyl-5-(2,3,5-trifluoro-4-hydroxyphenyl)octahydro-1H-inden-1-ol, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62533.59

構造登録者

Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (登録日: 2015-08-31, 公開日: 2016-05-04, 最終更新日: 2024-03-06)

• 主引用文献: Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W.; Predictive features of ligand-specific signaling through the estrogen receptor.; Mol.Syst.Biol., 12:864-864, 2016; PubMed: 27107013; DOI: 10.15252/msb.20156701

実験手法

X-RAY DIFFRACTION (2.24 Å)