5DI1
MAP4K4 in complex with an inhibitor
Summary for 5DI1
Entry DOI | 10.2210/pdb5di1/pdb |
Related | 4ZP5 |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 4, 4-{6-amino-5-[4-(methylsulfonyl)phenyl]pyridin-3-yl}phenol (3 entities in total) |
Functional Keywords | kinase, inhibitor, complex, medicinal chemistry, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O95819 |
Total number of polymer chains | 2 |
Total formula weight | 71237.80 |
Authors | |
Primary citation | Ammirati, M.,Bagley, S.W.,Bhattacharya, S.K.,Buckbinder, L.,Carlo, A.A.,Conrad, R.,Cortes, C.,Dow, R.L.,Dowling, M.S.,El-Kattan, A.,Ford, K.,Guimaraes, C.R.,Hepworth, D.,Jiao, W.,LaPerle, J.,Liu, S.,Londregan, A.,Loria, P.M.,Mathiowetz, A.M.,Munchhof, M.,Orr, S.T.,Petersen, D.N.,Price, D.A.,Skoura, A.,Smith, A.C.,Wang, J. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. Acs Med.Chem.Lett., 6:1128-1133, 2015 Cited by PubMed: 26617966DOI: 10.1021/acsmedchemlett.5b00215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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