5DGM
Crystal structure of human FPPS in complex with monophosphonate compound 7
Summary for 5DGM
Entry DOI | 10.2210/pdb5dgm/pdb |
Descriptor | Farnesyl pyrophosphate synthase, {2-[(phosphonomethyl)carbamoyl]-1H-benzo[g]indol-1-yl}acetic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | transferase, isoprene biosynthesis, cholesterol biosynthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40641.10 |
Authors | Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-08-28, release date: 2016-07-13, Last modification date: 2024-05-08) |
Primary citation | Jahnke, W.,Bold, G.,Marzinzik, A.L.,Ofner, S.,Pelle, X.,Cotesta, S.,Bourgier, E.,Lehmann, S.,Henry, C.,Hemmig, R.,Stauffer, F.,Hartwieg, J.C.,Green, J.R.,Rondeau, J.M. A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54:14575-14579, 2015 Cited by PubMed: 26457482DOI: 10.1002/anie.201507064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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