5DFB
Crystal structure of BRD2(BD2) mutant W370F in the free form
Summary for 5DFB
Entry DOI | 10.2210/pdb5dfb/pdb |
Descriptor | Bromodomain-containing protein 2, NICKEL (II) ION, NONAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | transcription factors, bet bromodomains, protein mutation engineering, molecular probes, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P25440 |
Total number of polymer chains | 1 |
Total formula weight | 13901.65 |
Authors | Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2015-08-26, release date: 2015-11-11, Last modification date: 2024-01-10) |
Primary citation | Baud, M.G.,Lin-Shiao, E.,Zengerle, M.,Tallant, C.,Ciulli, A. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59:1492-1500, 2016 Cited by PubMed: 26367539DOI: 10.1021/acs.jmedchem.5b01135 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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