5DEW
Crystal structure of PAK1 in complex with an inhibitor compound 5
Summary for 5DEW
Entry DOI | 10.2210/pdb5dew/pdb |
Related | 5DEY 5DFP |
Descriptor | Serine/threonine-protein kinase PAK 1, 8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13153 |
Total number of polymer chains | 2 |
Total formula weight | 67580.59 |
Authors | |
Primary citation | Ndubaku, C.O. Design of Selective PAK1 Inhibitor G-5555: Improving Proper-ties by Employing an Unorthodox Low-pKa Polar Moiety To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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