5DES

2009 H1N1 PA endonuclease domain

Summary for 5DES

Entry DOI	10.2210/pdb5des/pdb
Related	5CCY 5CGV 5CL0 5CZN 5D2O 5D42 5D4G 5D8U 5D9J 5DBS 5DEB
Descriptor	Polymerase acidic protein, MANGANESE (II) ION (3 entities in total)
Functional Keywords	influenza, resistance, endonuclease, inhibitor, hydrolase
Biological source	Influenza A virus More
Total number of polymer chains	1
Total formula weight	22080.04
Authors	Kumar, G.,White, S.W. (deposition date: 2015-08-25, release date: 2016-03-16, Last modification date: 2023-09-27)
Primary citation	Song, M.S.,Kumar, G.,Shadrick, W.R.,Zhou, W.,Jeevan, T.,Li, Z.,Slavish, P.J.,Fabrizio, T.P.,Yoon, S.W.,Webb, T.R.,Webby, R.J.,White, S.W. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113:3669-3674, 2016 Cited by PubMed: 26976575 DOI: 10.1073/pnas.1519772113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation