5DC5
Crystal structure of D176N HDAC8 in complex with M344
Summary for 5DC5
Entry DOI | 10.2210/pdb5dc5/pdb |
Related | 5DC6 5DC7 5DC8 |
Descriptor | Histone deacetylase 8, POTASSIUM ION, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ... (5 entities in total) |
Functional Keywords | histone deacetylase 8, arginase fold, deacetylase, enzyme-inhibitor complex, hydrolase-hydrloase inhibitor complex, hydrolase/hydrloase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 87285.81 |
Authors | Decroos, C.,Lee, M.S.,Christianson, D.W. (deposition date: 2015-08-23, release date: 2016-02-03, Last modification date: 2023-09-27) |
Primary citation | Gantt, S.M.,Decroos, C.,Lee, M.S.,Gullett, L.E.,Bowman, C.M.,Christianson, D.W.,Fierke, C.A. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry, 55:820-832, 2016 Cited by PubMed: 26806311DOI: 10.1021/acs.biochem.5b01327 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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