5DC0
CRYSTAL STRUCTURE OF MONOBODY GG3/ABL1 SH2 DOMAIN COMPLEX
Summary for 5DC0
Entry DOI | 10.2210/pdb5dc0/pdb |
Related | 5DC4 5DC9 |
Descriptor | Fibronectin, Tyrosine-protein kinase ABL1 (3 entities in total) |
Functional Keywords | engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, tyrosine-protein kinase, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 23437.98 |
Authors | Wojcik, J.B.,Grabe, G.,Koide, S. (deposition date: 2015-08-22, release date: 2016-03-02, Last modification date: 2024-03-06) |
Primary citation | Wojcik, J.,Lamontanara, A.J.,Grabe, G.,Koide, A.,Akin, L.,Gerig, B.,Hantschel, O.,Koide, S. Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface. J.Biol.Chem., 291:8836-8847, 2016 Cited by PubMed: 26912659DOI: 10.1074/jbc.M115.707901 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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