5D9R

Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6

5D9R の概要

• エントリーDOI: 10.2210/pdb5d9r/pdb
• 分子名称: Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic (2 entities in total)
• 機能のキーワード: plastid division machinery, biosynthetic protein
• 由来する生物種: Arabidopsis thaliana (Mouse-ear cress)
• 細胞内の位置: Plastid, chloroplast inner membrane ; Single- pass membrane protein : Q9FIG9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20522.01

構造登録者

Radhakrishnan, A.,Kumar, N.,Su, C.-C.,Chou, T.-H.,Yu, E. (登録日: 2015-08-18, 公開日: 2015-11-11, 最終更新日: 2024-03-06)

主引用文献

Kumar, N.,Radhakrishnan, A.,Su, C.C.,Osteryoung, K.W.,Yu, E.W.
Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.
Protein Sci., 25:523-529, 2016

PubMed Abstract: The chloroplast division machinery is composed of numerous proteins that assemble as a large complex to divide double-membraned chloroplasts through binary fission. A key mediator of division-complex formation is ARC6, a chloroplast inner envelope protein and evolutionary descendant of the cyanobacterial cell division protein Ftn2. ARC6 connects stromal and cytosolic contractile rings across the two membranes through interaction with an outer envelope protein within the intermembrane space (IMS). The ARC6 IMS region bears a structurally uncharacterized domain of unknown function, DUF4101, that is highly conserved among ARC6 and Ftn2 proteins. Here we report the crystal structure of this domain from Arabidopsis thaliana ARC6. The domain forms an α/β barrel open towards the outer envelope membrane but closed towards the inner envelope membrane. These findings provide new clues into how ARC6 and its homologs contribute to chloroplast and cyanobacterial cell division.

PubMed: 26452626
DOI: 10.1002/pro.2825

実験手法

X-RAY DIFFRACTION (2.052 Å)