5D6C

Structure of 4497 Fab bound to synthetic wall teichoic acid fragment

Summary for 5D6C

• Entry DOI: 10.2210/pdb5d6c/pdb
• Descriptor: 4497 antibody IgK (VL and CL), 4497 antibody IgG1 (VH and CH1), CALCIUM ION, ... (7 entities in total)
• Functional Keywords: staphylococcus aureus wall teichoic acid antibody mrsa, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 97766.68

Authors

Lupardus, P.J.,Fong, R. (deposition date: 2015-08-12, release date: 2015-11-11, Last modification date: 2020-07-29)

• Primary citation: Lehar, S.M.,Pillow, T.,Xu, M.,Staben, L.,Kajihara, K.K.,Vandlen, R.,DePalatis, L.,Raab, H.,Hazenbos, W.L.,Morisaki, J.H.,Kim, J.,Park, S.,Darwish, M.,Lee, B.C.,Hernandez, H.,Loyet, K.M.,Lupardus, P.,Fong, R.,Yan, D.,Chalouni, C.,Luis, E.,Khalfin, Y.,Plise, E.,Cheong, J.,Lyssikatos, J.P.,Strandh, M.,Koefoed, K.,Andersen, P.S.,Flygare, J.A.,Wah Tan, M.,Brown, E.J.,Mariathasan, S.; Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.; Nature, 527:323-328, 2015; PubMed: 26536114; DOI: 10.1038/nature16057

Experimental method

X-RAY DIFFRACTION (1.72 Å)