5D69

Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound

Summary for 5D69

• Entry DOI: 10.2210/pdb5d69/pdb
• Descriptor: Calpain small subunit 1, CALCIUM ION, (2E,2'Z)-2,2'-disulfanediylbis[3-(4-iodophenyl)prop-2-enoic acid], ... (5 entities in total)
• Functional Keywords: pef(s), domain vi, calcium binding domain, cysteine protease, mercaptoacrylic acid, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P04632
• Total number of polymer chains: 2
• Total formula weight: 41670.35

Authors

Adams, S.E.,Robinson, E.J.,Rizkallah, P.J.,Miller, D.J.,Hallett, M.B.,Allemann, R.K. (deposition date: 2015-08-11, release date: 2015-09-02, Last modification date: 2024-05-08)

• Primary citation: Adams, S.E.,Robinson, E.J.,Miller, D.J.,Rizkallah, P.J.,Hallett, M.B.,Allemann, R.K.; Conformationally restricted calpain inhibitors.; Chem Sci, 6:6865-6871, 2015; PubMed: 28757975; DOI: 10.1039/c5sc01158b

Experimental method

X-RAY DIFFRACTION (1.97 Å)