5D4C

Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP

Summary for 5D4C

• Entry DOI: 10.2210/pdb5d4c/pdb
• Related: 4G7H 5D4D 5D4E
• Descriptor: DNA-directed RNA polymerase subunit alpha, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... (13 entities in total)
• Functional Keywords: rna polymerase, transcription initiation, bacterial, ncin, non-canonical initiating nucleotide, primer-dependent initiation, dna, single-stranded, dna-directed rna polymerases, gene expression regulation, promoter regions, genetic, protein conformation, sigma factor, thermus thermophilus, transcription, transcription-dna complex, transcription/dna
• Biological source: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579); More
• Cellular location: Cytoplasm : Q5SKW1
• Total number of polymer chains: 16
• Total formula weight: 889388.44

Authors

Zhang, Y.,Ebright, R.H. (deposition date: 2015-08-07, release date: 2016-07-06, Last modification date: 2024-07-03)

• Primary citation: Bird, J.G.,Zhang, Y.,Tian, Y.,Panova, N.,Barvik, I.,Greene, L.,Liu, M.,Buckley, B.,Krasny, L.,Lee, J.K.,Kaplan, C.D.,Ebright, R.H.,Nickels, B.E.; The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.; Nature, 535:444-447, 2016; PubMed: 27383794; DOI: 10.1038/nature18622

Experimental method

X-RAY DIFFRACTION (3.28 Å)