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5D2B

Crystal structure of a mutated catalytic domain of Human MMP12 in complex with an hydroxamate analogue of RXP470

Summary for 5D2B
Entry DOI10.2210/pdb5d2b/pdb
DescriptorMacrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmetzincin, matrix metallo elastase, mmp12, human, rxp470, macrophage, hydrolase, hydroxamate based inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted, extracellular space, extracellular matrix : P39900
Total number of polymer chains1
Total formula weight18524.78
Authors
Rouanet-Mehouas, C.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2015-08-05, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citationRouanet-Mehouas, C.,Czarny, B.,Beau, F.,Cassar-Lajeunesse, E.,Stura, E.A.,Dive, V.,Devel, L.
Zinc-Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity.
J. Med. Chem., 60:403-414, 2017
Cited by
PubMed: 27996256
DOI: 10.1021/acs.jmedchem.6b01420
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.2 Å)
Structure validation

221051

數據於2024-06-12公開中

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