5D1D
Crystal structure of P91L-Y306F HDAC8 in complex with a tetrapeptide substrate
Summary for 5D1D
Entry DOI | 10.2210/pdb5d1d/pdb |
Related | 5D1B 5D1C |
Descriptor | Histone deacetylase 8, HDAC8 Fluor de Lys tetrapeptide substrate, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase, histone deacetylase, arginase/deacetylase fold, enzyme substrate complex |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 88425.24 |
Authors | Decroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. (deposition date: 2015-08-04, release date: 2015-10-21, Last modification date: 2023-11-15) |
Primary citation | Decroos, C.,Christianson, N.H.,Gullett, L.E.,Bowman, C.M.,Christianson, K.E.,Deardorff, M.A.,Christianson, D.W. Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Biochemistry, 54:6501-6513, 2015 Cited by PubMed: 26463496DOI: 10.1021/acs.biochem.5b00881 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.011 Å) |
Structure validation
Download full validation report