5CZK

Structure of E. coli beta-glucuronidase bound with a novel, potent inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea

5CZK の概要

• エントリーDOI: 10.2210/pdb5czk/pdb
• 関連するPDBエントリー: 4JKK 4JKL 4JKM
• 分子名称: Beta-glucuronidase, 1-[(6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(4-hydroxyphenyl)thiourea (3 entities in total)
• 機能のキーワード: alpha/beta barrel, sugar-binding domain, beta-sandwich domain, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 139508.19

構造登録者

Roberts, A.R.,Wallace, B.R.,Redinbo, M.R. (登録日: 2015-07-31, 公開日: 2015-10-14, 最終更新日: 2019-12-04)

• 主引用文献: Wallace, B.D.,Roberts, A.B.,Pollet, R.M.,Ingle, J.D.,Biernat, K.A.,Pellock, S.J.,Venkatesh, M.K.,Guthrie, L.,O'Neal, S.K.,Robinson, S.J.,Dollinger, M.,Figueroa, E.,McShane, S.R.,Cohen, R.D.,Jin, J.,Frye, S.V.,Zamboni, W.C.,Pepe-Ranney, C.,Mani, S.,Kelly, L.,Redinbo, M.R.; Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.; Chem.Biol., 22:1238-1249, 2015; PubMed: 26364932; DOI: 10.1016/j.chembiol.2015.08.005

実験手法

X-RAY DIFFRACTION (2.39 Å)