5CZB

HCV NS5B IN COMPLEX WITH LIGAND IDX17119-5

5CZB の概要

• エントリーDOI: 10.2210/pdb5czb/pdb
• 分子名称: NS5B, 1-[4-(7-amino-5-methylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]-3-{[(R)-(2,4-dimethylphenyl)(methoxy)phosphoryl]amino}-1H-pyrazole-4-carboxylic acid, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: hcv polymerase, idenix, inhibitor, proteros biostructures gmbh, replication
• 由来する生物種: Hepatitis C virus subtype 1b (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129021.89

構造登録者

Pierra, C.,Dousson, C.,Augustin, M. (登録日: 2015-07-31, 公開日: 2016-06-15, 最終更新日: 2024-05-01)

• 主引用文献: Pierra Rouviere, C.,Amador, A.,Badaroux, E.,Convard, T.,Da Costa, D.,Dukhan, D.,Griffe, L.,Griffon, J.F.,LaColla, M.,Leroy, F.,Liuzzi, M.,Loi, A.G.,McCarville, J.,Mascia, V.,Milhau, J.,Onidi, L.,Paparin, J.L.,Rahali, R.,Sais, E.,Seifer, M.,Surleraux, D.,Standring, D.,Dousson, C.; Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.; Bioorg.Med.Chem.Lett., 26:4536-4541, 2016; PubMed: 27520942; DOI: 10.1016/j.bmcl.2016.01.042

実験手法

X-RAY DIFFRACTION (1.96 Å)