5CYU

Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system.

5CYU の概要

• エントリーDOI: 10.2210/pdb5cyu/pdb
• 分子名称: Conserved membrane protein (2 entities in total)
• 機能のキーワード: membrane protein, virulence, protein secretion, mycobacteria, structural genomics, psi-2, protein structure initiative, tb structural genomics consortium, tbsgc
• 由来する生物種: Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42997.34

構造登録者

Arbing, M.A.,Chan, S.,Kahng, S.,Kim, J.,Eisenberg, D.S.,TB Structural Genomics Consortium (TBSGC) (登録日: 2015-07-30, 公開日: 2015-08-12, 最終更新日: 2024-10-30)

主引用文献

Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16:5-5, 2016

PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

PubMed: 26922638
DOI: 10.1186/s12900-016-0056-6

実験手法

X-RAY DIFFRACTION (3.07 Å)