5CW8

Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-4-cholesten-26-oyl-CoA

Summary for 5CW8

• Entry DOI: 10.2210/pdb5cw8/pdb
• Descriptor: HTH-type transcriptional repressor KstR, S-{1-[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,7-dihydroxy-6,6-dimethyl-3-oxido-8,12 -dioxo-2,4-dioxa-9,13-diaza-3lambda~5~-phosphapentadecan-15-yl} (2S,6R)-6-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthren-17-yl]-2-methylheptanethioate (non-preferred name), TRIETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: transcriptional repressor, tetr family transcriptional repressor, cholesterol catabolism, coa thioester ligand, structural genomics, tb structural genomics consortium, tbsgc, transcription regulator
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 47023.51

Authors

Ho, N.A.T.,Dawes, S.,Kendall, S.,Casabon, I.,Crowe, A.M.,Baker, E.N.,Eltis, L.D.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2015-07-27, release date: 2016-02-17, Last modification date: 2023-09-27)

• Primary citation: Ho, N.A.,Dawes, S.S.,Crowe, A.M.,Casabon, I.,Gao, C.,Kendall, S.L.,Baker, E.N.,Eltis, L.D.,Lott, J.S.; The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.; J.Biol.Chem., 291:7256-7266, 2016; PubMed: 26858250; DOI: 10.1074/jbc.M115.707760

Experimental method

X-RAY DIFFRACTION (2.6 Å)