5CSW

B-RAF in complex with Dabrafenib

Summary for 5CSW

• Entry DOI: 10.2210/pdb5csw/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, Dabrafenib, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: kinase, proteros biostructures gmbh, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 65133.96

Authors

Bader, G.,Stadtmuller, H.,Steurer, S. (deposition date: 2015-07-23, release date: 2016-03-09, Last modification date: 2024-01-10)

• Primary citation: Waizenegger, I.C.,Baum, A.,Steurer, S.,Stadtmuller, H.,Bader, G.,Schaaf, O.,Garin-Chesa, P.,Schlattl, A.,Schweifer, N.,Haslinger, C.,Colbatzky, F.,Mousa, S.,Kalkuhl, A.,Kraut, N.,Adolf, G.R.; A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation.; Mol.Cancer Ther., 15:354-365, 2016; PubMed: 26916115; DOI: 10.1158/1535-7163.MCT-15-0617

Experimental method

X-RAY DIFFRACTION (2.66 Å)