5CP9

The structure of the NK1 fragment of HGF/SF complexed with MB605

Summary for 5CP9

Entry DOI	10.2210/pdb5cp9/pdb
Descriptor	Hepatocyte growth factor, 3-(furan-2-yl)propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	hgf/sf, nk1 fragment, fragment based drug discovery, growth factor, cell cycle, hormone, new chemical entity
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	42546.75
Authors	Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. (deposition date: 2015-07-21, release date: 2015-08-12, Last modification date: 2024-01-10)
Primary citation	Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6:6147-6157, 2015 Cited by PubMed: 30090230 DOI: 10.1039/c5sc02155c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation