5CP9

The structure of the NK1 fragment of HGF/SF complexed with MB605

5CP9 の概要

• エントリーDOI: 10.2210/pdb5cp9/pdb
• 分子名称: Hepatocyte growth factor, 3-(furan-2-yl)propanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: hgf/sf, nk1 fragment, fragment based drug discovery, growth factor, cell cycle, hormone, new chemical entity
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42546.75

構造登録者

Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. (登録日: 2015-07-21, 公開日: 2015-08-12, 最終更新日: 2024-01-10)

• 主引用文献: Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.,Ascher, D.B.,Blundell, T.L.,Gherardi, E.; Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.; Chem Sci, 6:6147-6157, 2015; PubMed: 30090230; DOI: 10.1039/c5sc02155c

実験手法

X-RAY DIFFRACTION (1.9 Å)