5CON

X-ray crystal structure of wild type HIV-1 protease in complex with GRL-015

5CON の概要

• エントリーDOI: 10.2210/pdb5con/pdb
• 関連するPDBエントリー: 4HLA 5COK 5COO
• 分子名称: HIV-1 protease, (3R,3aS,4S,7aS)-3-hydroxyhexahydro-4H-furo[2,3-b]pyran-4-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate (3 entities in total)
• 機能のキーワード: grl-015, hiv-1 protease, protease-inhibitor, darunavir, tp-thf, nonpeptidic, hydroxyl, o-methoxy., hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22198.24

構造登録者

Yedidi, R.S.,Hayashi, H.,Aoki, M.,Das, D.,Ghosh, A.K.,Mitsuya, H. (登録日: 2015-07-20, 公開日: 2016-01-13, 最終更新日: 2024-03-06)

• 主引用文献: Aoki, M.,Hayashi, H.,Yedidi, R.S.,Martyr, C.D.,Takamatsu, Y.,Aoki-Ogata, H.,Nakamura, T.,Nakata, H.,Das, D.,Yamagata, Y.,Ghosh, A.K.,Mitsuya, H.; C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.; J.Virol., 90:2180-2194, 2015; PubMed: 26581995; DOI: 10.1128/JVI.01829-15

実験手法

X-RAY DIFFRACTION (1.8 Å)