5CNR
Crystal structure-guided design of self-assembling RNA nano triangles
Summary for 5CNR
| Entry DOI | 10.2210/pdb5cnr/pdb |
| Related | 4P97 |
| Descriptor | RNA (5'-R(*GP*UP*CP*UP*AP*CP*CP*CP*AP*CP*CP*UP*CP*GP*CP*C)-3'), RNA (5'-R(*AP*GP*AP*GP*GP*AP*CP*GP*GP*CP*G)-3'), CHLORIDE ION (3 entities in total) |
| Functional Keywords | seneca valley virus, nanotriangle, self-assembly, rna |
| Biological source | Seneca valley virus More |
| Total number of polymer chains | 4 |
| Total formula weight | 17221.97 |
| Authors | Boerneke, M.,Dibrov, S.,Hermann, T. (deposition date: 2015-07-18, release date: 2016-03-09, Last modification date: 2023-09-27) |
| Primary citation | Boerneke, M.A.,Dibrov, S.M.,Hermann, T. Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles. Angew.Chem.Int.Ed.Engl., 55:4097-4100, 2016 Cited by PubMed Abstract: RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 Å resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle architecture involved RNA corner motifs that were derived from ligand-responsive RNA switches, which offer the opportunity to control self-assembly and dissociation. PubMed: 26914842DOI: 10.1002/anie.201600233 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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