5CNM

mGluR3 complexed with glutamate analog

Summary for 5CNM

• Entry DOI: 10.2210/pdb5cnm/pdb
• Related: 5CNI 5CNJ 5CNK
• Descriptor: Metabotropic glutamate receptor 3, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: glutamate receptor, ligand, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Multi-pass membrane protein : Q14832
• Total number of polymer chains: 1
• Total formula weight: 59252.13

Authors

Monn, J.A.,Clawson, D.K.,McKinzie, D. (deposition date: 2015-07-17, release date: 2015-09-09, Last modification date: 2015-10-07)

• Primary citation: Monn, J.A.,Prieto, L.,Taboada, L.,Hao, J.,Reinhard, M.R.,Henry, S.S.,Beadle, C.D.,Walton, L.,Man, T.,Rudyk, H.,Clark, B.,Tupper, D.,Baker, S.R.,Lamas, C.,Montero, C.,Marcos, A.,Blanco, J.,Bures, M.,Clawson, D.K.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.,Carter, J.H.,Getman, B.G.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.; Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.; J.Med.Chem., 58:7526-7548, 2015; PubMed: 26313429; DOI: 10.1021/acs.jmedchem.5b01124

Experimental method

X-RAY DIFFRACTION (2.84 Å)