5CNM

mGluR3 complexed with glutamate analog

5CNM の概要

• エントリーDOI: 10.2210/pdb5cnm/pdb
• 関連するPDBエントリー: 5CNI 5CNJ 5CNK
• 分子名称: Metabotropic glutamate receptor 3, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: glutamate receptor, ligand, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : Q14832
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59252.13

構造登録者

Monn, J.A.,Clawson, D.K.,McKinzie, D. (登録日: 2015-07-17, 公開日: 2015-09-09, 最終更新日: 2015-10-07)

• 主引用文献: Monn, J.A.,Prieto, L.,Taboada, L.,Hao, J.,Reinhard, M.R.,Henry, S.S.,Beadle, C.D.,Walton, L.,Man, T.,Rudyk, H.,Clark, B.,Tupper, D.,Baker, S.R.,Lamas, C.,Montero, C.,Marcos, A.,Blanco, J.,Bures, M.,Clawson, D.K.,Atwell, S.,Lu, F.,Wang, J.,Russell, M.,Heinz, B.A.,Wang, X.,Carter, J.H.,Getman, B.G.,Catlow, J.T.,Swanson, S.,Johnson, B.G.,Shaw, D.B.,McKinzie, D.L.; Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.; J.Med.Chem., 58:7526-7548, 2015; PubMed: 26313429; DOI: 10.1021/acs.jmedchem.5b01124

実験手法

X-RAY DIFFRACTION (2.84 Å)