5CM4

Crystal structure of human Frizzled 4 Cysteine-Rich Domain (CRD)

Summary for 5CM4

• Entry DOI: 10.2210/pdb5cm4/pdb
• Related: 5CL1
• Descriptor: Frizzled-4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: wnt signaling, norrin signaling, frizzled 4 extracelluar domain, cysteine-rich domain, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29382.69

Authors

Ke, J.,Parker, N.,Gu, X.,Zhang, C.,Melcher, K.,Xu, H.E. (deposition date: 2015-07-16, release date: 2015-08-12, Last modification date: 2023-09-27)

• Primary citation: Shen, G.,Ke, J.,Wang, Z.,Cheng, Z.,Gu, X.,Wei, Y.,Melcher, K.,Xu, H.E.,Xu, W.; Structural basis of the Norrin-Frizzled 4 interaction.; Cell Res., 25:1078-1081, 2015; PubMed: 26227961; DOI: 10.1038/cr.2015.92

Experimental method

X-RAY DIFFRACTION (2.4 Å)