5CLU

THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH A SACCHARINE DERIVATIVE

5CLU の概要

• エントリーDOI: 10.2210/pdb5clu/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetic acid, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase ii, lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29331.37

構造登録者

D'Ambrosio, K.,De Simone, G. (登録日: 2015-07-16, 公開日: 2015-11-11, 最終更新日: 2024-01-10)

主引用文献

Langella, E.,D'Ambrosio, K.,D'Ascenzio, M.,Carradori, S.,Monti, S.M.,Supuran, C.T.,De Simone, G.
A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases.
Chemistry, 22:97-100, 2016

PubMed Abstract: Carboxylates are the least investigated class of inhibitors of carbonic anhydrases (CAs). Here we explain the versatility of binding of these molecules to CAs by examining a new adduct of hCA II with N-carboxymethyl-saccharin.

PubMed: 26507456
DOI: 10.1002/chem.201503748

実験手法

X-RAY DIFFRACTION (1.55 Å)