5CLS
Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31a
Summary for 5CLS
| Entry DOI | 10.2210/pdb5cls/pdb |
| Descriptor | Methionine aminopeptidase 2, COBALT (II) ION, DIMETHYL SULFOXIDE, ... (8 entities in total) |
| Functional Keywords | metap2, methionine aminopeptidase-2, inhibitor, spiroepoxytriazole, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 42511.54 |
| Authors | Janowski, R.,Miller, A.K.,Niessing, D. (deposition date: 2015-07-16, release date: 2016-01-13, Last modification date: 2019-11-20) |
| Primary citation | Morgen, M.,Jost, C.,Malz, M.,Janowski, R.,Niessing, D.,Klein, C.D.,Gunkel, N.,Miller, A.K. Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. Acs Chem.Biol., 11:1001-1011, 2016 Cited by PubMed: 26686773DOI: 10.1021/acschembio.5b00755 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report
