5CLP

Crystal Structure of CK2alpha with 3,4-dichlorophenethylamine bound

5CLP の概要

• エントリーDOI: 10.2210/pdb5clp/pdb
• 分子名称: Casein kinase II subunit alpha, 2-(3,4-dichlorophenyl)ethanamine, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P68400
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85203.49

構造登録者

Brear, P.,De Fusco, C.,Georgiou, K.H.,Spring, D.,Hyvonen, M. (登録日: 2015-07-16, 公開日: 2016-07-27, 最終更新日: 2024-01-10)

• 主引用文献: Brear, P.,De Fusco, C.,Hadje Georgiou, K.,Francis-Newton, N.J.,Stubbs, C.J.,Sore, H.F.,Venkitaraman, A.R.,Abell, C.,Spring, D.R.,Hyvonen, M.; Specific inhibition of CK2 alpha from an anchor outside the active site.; Chem Sci, 7:6839-6845, 2016; PubMed: 28451126; DOI: 10.1039/c6sc02335e

実験手法

X-RAY DIFFRACTION (1.684 Å)