5CI8

Crystal structure of human Tob in complex with inhibitor fragment 1

Summary for 5CI8

• Entry DOI: 10.2210/pdb5ci8/pdb
• Related: 5CI9
• Descriptor: Protein Tob1, pyrrolo[1,2-a]quinoxalin-4(5H)-one (2 entities in total)
• Functional Keywords: tob/btg family, inhibitor, complex, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P50616
• Total number of polymer chains: 1
• Total formula weight: 38649.26

Authors

Bai, Y.,Tashiro, S.,Nagatoishi, S.,Suzuki, T.,Tsumoto, K.,Bartlam, M.,Yamamoto, T. (deposition date: 2015-07-11, release date: 2015-11-18, Last modification date: 2015-12-09)

• Primary citation: Bai, Y.,Tashiro, S.,Nagatoishi, S.,Suzuki, T.,Yan, D.,Liu, R.,Tsumoto, K.,Bartlam, M.,Yamamoto, T.; Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach; Protein Cell, 6:924-928, 2015; PubMed: 26518565; DOI: 10.1007/s13238-015-0225-6

Experimental method

X-RAY DIFFRACTION (2.328 Å)