5CHP
T. maritima ThyX in complex with TyC5-03
Summary for 5CHP
Entry DOI | 10.2210/pdb5chp/pdb |
Descriptor | Thymidylate synthase ThyX, FLAVIN-ADENINE DINUCLEOTIDE, (2S)-2-[(3-hydroxy-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)sulfanyl]propanoic acid, ... (4 entities in total) |
Functional Keywords | thyx in complex with inhibitor, hydrolase |
Biological source | Thermotoga maritima |
Total number of polymer chains | 1 |
Total formula weight | 28780.75 |
Authors | Surade, S.,Luciani, R.,Saxena, P.,Santucci, M.,Ferrari, S.,Venturelli, A.,Marverti, G.,Ponterini, G.,Abell, C.A.,Blundell, T.L.,Costi, M.P. (deposition date: 2015-07-10, release date: 2016-10-19, Last modification date: 2024-01-10) |
Primary citation | Surade, S. Identification of inhibitors targeting substrate-binding site in Mycobacterium tuberculosis FAD-dependent Thymidylate synthase (ThyX) through Virtual Screening: A New study de-fining the binding mechanism of Inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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