5CGJ
Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.
Summary for 5CGJ
Entry DOI | 10.2210/pdb5cgj/pdb |
Descriptor | Kelch-like ECH-associated protein 1, SULFATE ION, (3S)-1-(4-{[(2,3,5,6-tetramethylphenyl)sulfonyl]amino}naphthalen-1-yl)pyrrolidine-3-carboxylic acid, ... (4 entities in total) |
Functional Keywords | beta propeller, inhibitor, complex, protein binding |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : Q9Z2X8 |
Total number of polymer chains | 1 |
Total formula weight | 37865.19 |
Authors | Schimanski-Breves, S.,Loenze, P.,Engel, C.K. (deposition date: 2015-07-09, release date: 2015-10-21, Last modification date: 2024-05-08) |
Primary citation | Winkel, A.F.,Engel, C.K.,Margerie, D.,Kannt, A.,Szillat, H.,Glombik, H.,Kallus, C.,Ruf, S.,Gussregen, S.,Riedel, J.,Herling, A.W.,von Knethen, A.,Weigert, A.,Brune, B.,Schmoll, D. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J.Biol.Chem., 290:28446-28455, 2015 Cited by PubMed: 26459563DOI: 10.1074/jbc.M115.678136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.36 Å) |
Structure validation
Download full validation report