5CGJ

Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.

5CGJ の概要

• エントリーDOI: 10.2210/pdb5cgj/pdb
• 分子名称: Kelch-like ECH-associated protein 1, SULFATE ION, (3S)-1-(4-{[(2,3,5,6-tetramethylphenyl)sulfonyl]amino}naphthalen-1-yl)pyrrolidine-3-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: beta propeller, inhibitor, complex, protein binding
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Cytoplasm : Q9Z2X8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37865.19

構造登録者

Schimanski-Breves, S.,Loenze, P.,Engel, C.K. (登録日: 2015-07-09, 公開日: 2015-10-21, 最終更新日: 2024-05-08)

• 主引用文献: Winkel, A.F.,Engel, C.K.,Margerie, D.,Kannt, A.,Szillat, H.,Glombik, H.,Kallus, C.,Ruf, S.,Gussregen, S.,Riedel, J.,Herling, A.W.,von Knethen, A.,Weigert, A.,Brune, B.,Schmoll, D.; Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.; J.Biol.Chem., 290:28446-28455, 2015; PubMed: 26459563; DOI: 10.1074/jbc.M115.678136

実験手法

X-RAY DIFFRACTION (3.36 Å)