5CGA

Structure of Hydroxyethylthiazole kinase ThiM from Staphylococcus aureus in complex with substrate analog 2-(1,3,5-trimethyl-1H-pyrazole-4-yl)ethanol

5CGA の概要

• エントリーDOI: 10.2210/pdb5cga/pdb
• 分子名称: Hydroxyethylthiazole kinase, 2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethanol, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: bacterial thiamine biosynthesis, hydroxyethylthiazole kinase, substrate analog, transferase
• 由来する生物種: Staphylococcus aureus MRSA252
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 179875.03

構造登録者

Kuenz, M.,Drebes, J.,Windshuegel, B.,Cang, H.,Wrenger, C.,Betzel, C. (登録日: 2015-07-09, 公開日: 2016-03-23, 最終更新日: 2018-03-07)

• 主引用文献: Drebes, J.,Kunz, M.,Windshugel, B.,Kikhney, A.G.,Muller, I.B.,Eberle, R.J.,Oberthur, D.,Cang, H.,Svergun, D.I.,Perbandt, M.,Betzel, C.,Wrenger, C.; Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.; Sci Rep, 6:22871-22871, 2016; PubMed: 26960569; DOI: 10.1038/srep22871

実験手法

X-RAY DIFFRACTION (1.87 Å)