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5CF0

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6

Summary for 5CF0
Entry DOI10.2210/pdb5cf0/pdb
DescriptorHeat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(isoquinolin-4-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide (3 entities in total)
Functional Keywordsheat shock protein 90, n-terminal domain, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight26150.28
Authors
Li, J.,Shi, F.,Xiong, B.,He, J.H. (deposition date: 2015-07-08, release date: 2016-07-13, Last modification date: 2023-11-08)
Primary citationLi, J.,Shi, F.,Chen, D.-Q.,Cao, H.-L.,Xiong, B.,Shen, J.-K.,He, J.-H.
FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90
Nucl.Sci.Tech., 26:060502-060502, 2015
Cited by
DOI: 10.13538/j.1001-8042/nst.26.060503
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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