5CF0

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ6

5CF0 の概要

• エントリーDOI: 10.2210/pdb5cf0/pdb
• 分子名称: Heat shock protein HSP 90-alpha, N-{3-[2,4-dihydroxy-5-(isoquinolin-4-yl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl}cyclopropanecarboxamide (3 entities in total)
• 機能のキーワード: heat shock protein 90, n-terminal domain, inhibitor, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26150.28

構造登録者

Li, J.,Shi, F.,Xiong, B.,He, J.H. (登録日: 2015-07-08, 公開日: 2016-07-13, 最終更新日: 2023-11-08)

• 主引用文献: Li, J.,Shi, F.,Chen, D.-Q.,Cao, H.-L.,Xiong, B.,Shen, J.-K.,He, J.-H.; FS23 binds to the N-terminal domain of human Hsp90: A novel small inhibitor for Hsp90; Nucl.Sci.Tech., 26:060502-060502, 2015; DOI: 10.13538/j.1001-8042/nst.26.060503

実験手法

X-RAY DIFFRACTION (1.8 Å)