5CDW
Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide
Summary for 5CDW
Entry DOI | 10.2210/pdb5cdw/pdb |
Descriptor | Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN (3 entities in total) |
Functional Keywords | sh2 domain, phosphotyrosine, ligand, w121g mutation, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P62993 |
Total number of polymer chains | 32 |
Total formula weight | 197821.62 |
Authors | Papaioannou, D.,Geibel, S.,Kunze, M.,Kay, C.,Waksman, G. (deposition date: 2015-07-05, release date: 2016-05-25, Last modification date: 2024-01-10) |
Primary citation | Papaioannou, D.,Geibel, S.,Kunze, M.B.,Kay, C.W.,Waksman, G. Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25:627-637, 2016 Cited by PubMed: 26645482DOI: 10.1002/pro.2856 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.602 Å) |
Structure validation
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