5CDW

Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide

5CDW の概要

• エントリーDOI: 10.2210/pdb5cdw/pdb
• 分子名称: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN (3 entities in total)
• 機能のキーワード: sh2 domain, phosphotyrosine, ligand, w121g mutation, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P62993
• タンパク質・核酸の鎖数: 32
• 化学式量合計: 197821.62

構造登録者

Papaioannou, D.,Geibel, S.,Kunze, M.,Kay, C.,Waksman, G. (登録日: 2015-07-05, 公開日: 2016-05-25, 最終更新日: 2024-01-10)

• 主引用文献: Papaioannou, D.,Geibel, S.,Kunze, M.B.,Kay, C.W.,Waksman, G.; Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide.; Protein Sci., 25:627-637, 2016; PubMed: 26645482; DOI: 10.1002/pro.2856

実験手法

X-RAY DIFFRACTION (2.602 Å)