5CDN
2.8A structure of etoposide with S.aureus DNA gyrase and DNA
Summary for 5CDN
Entry DOI | 10.2210/pdb5cdn/pdb |
Descriptor | DNA gyrase subunit A, DNA gyrase subunit B,DNA gyrase subunit B, DNA (5'-D(P*GP*AP*GP*CP*GP*TP*AP**GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*C)-3'), ... (10 entities in total) |
Functional Keywords | type iia topoisomerase, antibacterial, inhibitor, isomerase |
Biological source | Staphylococcus aureus More |
Cellular location | Cytoplasm : Q99XG5 P66937 |
Total number of polymer chains | 16 |
Total formula weight | 331179.05 |
Authors | Bax, B.D.,Srikannathasan, V.,Chan, P.F. (deposition date: 2015-07-04, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Chan, P.F.,Srikannathasan, V.,Huang, J.,Cui, H.,Fosberry, A.P.,Gu, M.,Hann, M.M.,Hibbs, M.,Homes, P.,Ingraham, K.,Pizzollo, J.,Shen, C.,Shillings, A.J.,Spitzfaden, C.E.,Tanner, R.,Theobald, A.J.,Stavenger, R.A.,Bax, B.D.,Gwynn, M.N. Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin. Nat Commun, 6:10048-10048, 2015 Cited by PubMed: 26640131DOI: 10.1038/ncomms10048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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