5CD5

Crystal structure of an immature VRC01-class antibody DRVIA7 from a Chinese donor bound to clade A/E HIV-1 gp120 core

Summary for 5CD5

• Entry DOI: 10.2210/pdb5cd5/pdb
• Related: 5CD3
• Descriptor: 93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ... (7 entities in total)
• Functional Keywords: vrc01, gp120, hiv-1, antibody, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 89978.61

Authors

Kong, L.,Wilson, I.A. (deposition date: 2015-07-03, release date: 2016-04-06, Last modification date: 2020-07-29)

• Primary citation: Kong, L.,Ju, B.,Chen, Y.,He, L.,Ren, L.,Liu, J.,Hong, K.,Su, B.,Wang, Z.,Ozorowski, G.,Ji, X.,Hua, Y.,Chen, Y.,Deller, M.C.,Hao, Y.,Feng, Y.,Garces, F.,Wilson, R.,Dai, K.,O'Dell, S.,McKee, K.,Mascola, J.R.,Ward, A.B.,Wyatt, R.T.,Li, Y.,Wilson, I.A.,Zhu, J.,Shao, Y.; Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.; Immunity, 44:939-950, 2016; PubMed: 27067056; DOI: 10.1016/j.immuni.2016.03.006

Experimental method

X-RAY DIFFRACTION (3.396 Å)