5CB0

Crystal structure and functional implications of the tandem-type universal stress protein UspE from Escherichia coli

5CB0 の概要

• エントリーDOI: 10.2210/pdb5cb0/pdb
• 分子名称: Universal stress protein E, 3-oxotetradecanoic acid (2 entities in total)
• 機能のキーワード: uspe, uspa superfamily, enterohemorrhagic escherichia coli, unknown function
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm : P0AAC0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71980.22

構造登録者

Xu, Y.,Quan, C.S.,Jin, X.,Jin, L.,Kim, J.S.,Guo, J.,Fan, S.,Ha, N.C. (登録日: 2015-06-30, 公開日: 2016-02-10, 最終更新日: 2023-11-08)

主引用文献

Xu, Y.,Guo, J.,Jin, X.,Kim, J.S.,Ji, Y.,Fan, S.,Ha, N.C.,Quan, C.S.
Crystal structure and functional implications of the tandem-type universal stress protein UspE from Escherichia coli.
Bmc Struct.Biol., 16:3-3, 2016

PubMed Abstract: The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. It has been shown that UspA family members are survival factors during cellular growth arrest. The structures and functions of the UspA family members control the growth of E. coli in animal hosts. While several UspA family members have known structures, the structure of E. coli UspE remains to be elucidated.

PubMed: 26865045
DOI: 10.1186/s12900-016-0053-9

実験手法

X-RAY DIFFRACTION (3.207 Å)