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5C9C

CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND

Summary for 5C9C
Entry DOI10.2210/pdb5c9c/pdb
DescriptorSerine/threonine-protein kinase B-raf, 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, ... (4 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P15056
Total number of polymer chains2
Total formula weight71379.71
Authors
Edwards, T.,Abendroth, J.,Chun, L. (deposition date: 2015-06-26, release date: 2015-07-15, Last modification date: 2023-09-27)
Primary citationPeng, S.B.,Henry, J.R.,Kaufman, M.D.,Lu, W.P.,Smith, B.D.,Vogeti, S.,Rutkoski, T.J.,Wise, S.,Chun, L.,Zhang, Y.,Van Horn, R.D.,Yin, T.,Zhang, X.,Yadav, V.,Chen, S.H.,Gong, X.,Ma, X.,Webster, Y.,Buchanan, S.,Mochalkin, I.,Huber, L.,Kays, L.,Donoho, G.P.,Walgren, J.,McCann, D.,Patel, P.,Conti, I.,Plowman, G.D.,Starling, J.J.,Flynn, D.L.
Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell, 28:384-398, 2015
Cited by
PubMed: 26343583
DOI: 10.1016/j.ccell.2015.08.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

건을2024-03-27부터공개중

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