5C9C
CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND
Summary for 5C9C
Entry DOI | 10.2210/pdb5c9c/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71379.71 |
Authors | Edwards, T.,Abendroth, J.,Chun, L. (deposition date: 2015-06-26, release date: 2015-07-15, Last modification date: 2023-09-27) |
Primary citation | Peng, S.B.,Henry, J.R.,Kaufman, M.D.,Lu, W.P.,Smith, B.D.,Vogeti, S.,Rutkoski, T.J.,Wise, S.,Chun, L.,Zhang, Y.,Van Horn, R.D.,Yin, T.,Zhang, X.,Yadav, V.,Chen, S.H.,Gong, X.,Ma, X.,Webster, Y.,Buchanan, S.,Mochalkin, I.,Huber, L.,Kays, L.,Donoho, G.P.,Walgren, J.,McCann, D.,Patel, P.,Conti, I.,Plowman, G.D.,Starling, J.J.,Flynn, D.L. Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Cancer Cell, 28:384-398, 2015 Cited by PubMed: 26343583DOI: 10.1016/j.ccell.2015.08.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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