5C8Y

Crystal structure of T2R-TTL-Plinabulin complex

Summary for 5C8Y

• Entry DOI: 10.2210/pdb5c8y/pdb
• Related: 5CA0 5CA1 5CB4
• Descriptor: Tubulin alpha, (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: inhibitor, complex, tubulin, structural protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 264764.03

Authors

Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. (deposition date: 2015-06-26, release date: 2015-11-04, Last modification date: 2024-03-20)

• Primary citation: Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J.; Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.; Febs J., 283:102-111, 2016; PubMed: 26462166; DOI: 10.1111/febs.13555

Experimental method

X-RAY DIFFRACTION (2.594 Å)