5C8Y

Crystal structure of T2R-TTL-Plinabulin complex

5C8Y の概要

関連するPDBエントリー5CA0 5CA1 5CB4
分子名称Tubulin alpha, Tubulin beta, Stathmin-4, ... (12 entities in total)
機能のキーワードinhibitor, complex, tubulin, structural protein
由来する生物種Rattus norvegicus (Rat)
詳細
細胞内の位置Golgi apparatus  P63043
ポリマー鎖数6
分子量合計264764.03
構造登録者
Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. (登録日: 2015-06-26, 公開日: 2015-11-04, 最終更新日: 2016-01-27)
主引用文献
Wang, Y.,Zhang, H.,Gigant, B.,Yu, Y.,Wu, Y.,Chen, X.,Lai, Q.,Yang, Z.,Chen, Q.,Yang, J.
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
Febs J., 283:102-111, 2016
PubMed: 26462166 (主引用文献が同じPDBエントリー)
DOI: 10.1111/febs.13555
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.594 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23410.1%0.7%11.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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